Results demonstrate major changes in both the solubility characteristics and polypeptide profiles of sperm nuclei upon insemination Evidence is presented which indicates that at fertilization the paternally derived chromatin acquires proteins of molecular weights greater than 80 000 and a nuclear protein composition similar to that of the Nanoparticles (NPs) in contact with protein-containing media such as biological fluids rapidly acquire a surface layer of proteins known as the protein corona The protein composition and structural properties of the protein corona are crucial for NP interactions with living cells Although much has been le Nano-bio interactions Recent Open Access Articles Environmental Science: Nano Recent

Current Research Projects

2020-7-24The aim of this project was to evaluate two protein extraction approaches alkaline and salt extraction and determine their impact on the structural and functional properties of camelina protein Protein yield content structural characteristics and functional properties of the produced camelina protein concentrates (CPC 70-80% protein) and

Changes in protein structural characteristics upon processing of gluten-free millet pasta Author links open overlay panel Catrin Tyl a Alessandra Marti a b Baraem P Ismail a This study compared processing-induced changes in protein characteristics of commercial pasta to fresh gluten-free pasta from proso millet varieties differing in

2015-10-27However this approach ignores the structural changes that can occur upon mutation which can alleviate clashes and position residues in conformations more favorable for interaction Accordingly much research has gone into the incorporation of flexibility into energetic calculations [8 10–12] However the method is computationally

Structural characteristics can be further influenced by protein-ligand binding interactions with a lipid membrane surface Structural features can be altered upon membrane binding causing disordered proteins to become more ordered in structure

Proso millet exhibits favorable agronomic and nutritional properties but is currently under-utilized in the northern hemisphere This study compared processing-induced changes in protein characteristics of commercial pasta to fresh gluten-free pasta from proso millet varieties differing in prolamin profile

Marked changes in electron transport through the blue

2012-7-241 Marked changes in electron transport through the blue copper protein azurin in the solid state upon deuteration Nadav Amdurskya b Israel Pechtc Mordechai Shevesb * and David Cahena * Departments of aMaterials and Interfaces bOrganic Chemistry and cImmunology Weiz- mann Institute of Science Rehovot 76100 Israel

These studies also emphasise how the relative importance of such characteristics is dependant upon the class of protein association with permanent associations generally displaying different characteristics to transient associations Thornton JM Structural characterisation and functional significance of transient protein-protein

2012-10-7Structure Article The Structural Basis of Peptide-Protein Binding Strategies Nir London 1 Dana Movshovitz-Attias 2 and Ora Schueler-Furman1 * 1Department of Microbiology and Molecular Genetics Institute for Medical Research IMRIC Faculty of Medicine The Hebrew University POB 12272 Jerusalem 91120 Israel 2School of Computer Science and Engineering The Hebrew University

We thoroughly analyzed the biases in the prediction of folding free energy changes upon point mutations (⁠ Δ Δ G 0 ⁠) and proposed some unbiased solutions We started by constructing a dataset S sym of experimentally measured Δ Δ G 0 s with an equal number of stabilizing and destabilizing mutations by collecting mutations for which the structure of both the wild-type and mutant protein

Nanoparticles (NPs) in contact with protein-containing media such as biological fluids rapidly acquire a surface layer of proteins known as the protein corona The protein composition and structural properties of the protein corona are crucial for NP interactions with living cells Although much has been le Nano-bio interactions Recent Open Access Articles Environmental Science: Nano Recent

2019-5-25Raman spectroscopy was used to elucidate structural changes of β-lactoglobulin (BLG) whey protein isolate (WPI) and bovine serum albumin (BSA) at 15% concentration as a function of pH (5 0 7 0 and 9 0) heating (80 C 30 min) and presence of 0 24% κ-carrageenan Three data-processing techniques were used to assist in identifying significant changes in Raman spectral data

2013-2-13When a protein binds to DNA a conformational change is often induced so that the protein will fit into the DNA structure Therefore quantitative analyses were conducted to understand the conformational changes in proteins The results showed that conformational changes in DNA interfaces are more frequent than in non-interfaces and DNA interfaces have more conformational variations in

Structural characteristics can be further influenced by protein-ligand binding interactions with a lipid membrane surface Structural features can be altered upon membrane binding causing disordered proteins to become more ordered in structure

Sequence feature

2010-11-2Protein destabilization is a common mechanism by which amino acid substitutions cause human diseases Although several machine learning methods have been reported for predicting protein stability changes upon amino acid substitutions the previous studies did not utilize relevant sequence features representing biological knowledge for classifier construction

2020-7-24The aim of this project was to evaluate two protein extraction approaches alkaline and salt extraction and determine their impact on the structural and functional properties of camelina protein Protein yield content structural characteristics and functional properties of the produced camelina protein concentrates (CPC 70-80% protein) and

article{osti_22606154 title = {Biophysical characterization of the structural change of Nopp140 an intrinsically disordered protein in the interaction with CK2α} author = {Na Jung-Hyun and Biomedical Research Institute Korea Institute of Science and Technology Seoul 02792 and Department of Chemistry and Nano Science Ewha Womans

2012-6-18We applied logistic regression to learn the structural change upon amino acid change Logistic regression is a parameter-free machine-learning algorithm we adhered to an implementation offered by the LIBLINEAR package (L2-regularized logistic regression dual) Many protein features may be relevant for the given prediction task

2020-4-10network structure Molecular interactions upon myofibrillar protein (MP) heat-gelation are central to understand how these could affect textural properties of these meat products MP constitutes about 55% to 60% of the total muscle protein It is mainly composed of myosin and actin and is an important structural protein group in meat proteins [2]

2012-11-14characteristics The spectral properties of the chromophore in mutants of PYP are a good indicator for structural perturbations in the protein PYP has a low chromophore emission 2 indicating that the PYP binding pocket is adjusted to promote photochemistry over fluorescence Changes in the PYP binding pocket cause higher fluorescence

The structural data together with biochemical experiments show that Get1 and Get2 use adjacent partially overlapping binding sites and that both can bind simultaneously to Get3 Docking to the Get1/2 complex allows for conformational changes in Get3 that are required for TA protein insertion

2017-2-14Structural Changes Underlying Allostery in Group II Chaperonins Keith R Willison1 * 1Section of Cell and Molecular Biology Institute of Cancer Research 237 Fulham Road London SW3 6JB UK *Correspondence: keith willisonicr ac uk DOI 10 1016/j str 2011 05 008